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  James Hittle


A protein expert, in particular on purification of proteins; making antibodies and so on.
Work on anything that Tim asks to do, including being a good chief - good at BBQ and cutting roasted pigs.
A huge girls lover, and in return, loved by girls.











Technical specialist


Fox Chase Cancer Center
7701 Burholme Ave
Philadelphia, PA 19111

Lab tel.: 215 728-4311
Fax: 215 728-2412


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Yen Lab Home |Research | People| Publications| Reference






Huang H, Hittle J, Zappacosta F, Annan R, Hershko A, Yen TJ 
Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension and mitotic exit
J Cell Biol. 2008 (in press)
Eytan E, Braunstein I, Ganoth D, Teichner A, Hittle JC, Yen TJ, Hershko A. 
Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20
Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9181-5
Liu ST, Chan GK, Hittle JC, Fujii G, Lees E, Yen TJ.
Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores
Mol Biol Cell. 2003 Apr;14(4):1638-51

Liu ST, Hittle JC, Jablonski SA, Campbell MS, Yoda K, Yen TJ.
Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis
Nat Cell Biol. 2003 Apr;5(4):341-5 

Daniel R, Katz RA, Merkel G, Hittle JC, Yen TJ, Skalka AM.
Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses
Mol Cell Biol. 2001 Feb;21(4):1164-72. Erratum in: Mol Cell Biol 2001 Apr;21(7):2617

Chan GK, Jablonski SA, Sudakin V, Hittle JC, Yen TJ.
Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC 
J Cell Biol. 1999 Sep 6;146(5):941-54

Gately DP, Hittle JC, Chan GK, Yen TJ.
Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity 
Mol Biol Cell. 1998 Sep;9(9):2361-74